MECP2 Duplication Syndrome Monkeys

An important step forward in research on MECP2 Duplication Syndrome

MECP2MomkeysResearchers at the Institute of Neuroscience, Key Laboratory of Primate Neurobiology, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences reported in Nature about some developmental/behavioral aspects of MECP2 Duplication Syndrome in transgenic monkeys with MECP2 overexpression.

-Zhen Liu, et al. (2016 January 25). Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature, doi:10.1038/nature16533

The New York Times also published an article on this research today (15 January 2016) that includes a short video clip demonstrating some behavioral differences between the MECP2 over expressed monkeys and those with typical MECP2 levels. Both articles point to this research as an important step toward better animal models for studying autistic behaviour. While this is not the main thrust of research on MECP2 Duplication Syndrome, the prominence of these transgenic primates may help to encourage and enable research on the syndrome. In addition, th availability fo transgenic primates with MECP2 Duplication will likely become important as treatments for the syndrome get closer to being applied to humans affected by the syndrome.

Thanks to Dr. Sarika Peters for bringing this study to my attention.






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