Susceptability to Influenza in MECP2 Duplication

mouseRespiratory infections are a major challenge for individuals with MECP2 Duplication Syndrome. They are a major source of illness and are frequently life threatening. Most of the focus on studying these infections has focused on bacterial pneumonia. A recent study, however, looked at the effects of influenza A, a virus, on MECP2 Duplication laboratory mice.The researchers found that the MECP2 Duplication Syndrome Mice were extremely vulnerable to influenza A and had difficulty mounting an appropriate immune response. Most families are probably already aware that influenza is a significant risk to their family members with MECP2 Duplication Syndrome, but this research lends additional evidence that the flu is a major threat. While it is unclear how effective flu vaccine will be in individuals with MECP2 Duplication, this finding provides additional reasons to get flu shots for your family member with the MECP2 Duplication Syndrome and for everyone else who comes in contact with your family member. Nasal spray vaccine (and other live vaccines) are typically NOT recommended.

The abstract of the study can be found here

Cronk, J., Kim,T., Moser, E., Sharma,A., Braciale,T., & Kipnis, J. (2015). Increased susceptibility to influenza A in a mouse model of MeCP2 duplication syndrome (VIR2P.1163)  The Journal of Immunology,  194:75.2


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