Some of the earliest research on MECP2 gene and protein focused on its role in the circadian cycle that regulates sleep and wakefulness . Now, researchers from Barcelona have taken that research a step further. They showed that the highest levels of MeCP2 protein occurred during the sleep phase and lowest during the awake phase.
This research could help explain some things that have been sometimes observed in children with MECP2 Duplication Syndrome: (1) More seizures observed when trying to wake up, (2) greater disorder in brain wave patterns and increasing numbers of seizure spikes during sleep, and (3) disordered sleeping patterns, too much sleep during the day and being wakeful at night. Nevertheless, more work needs to be done to determine the implications of this research for individuals with MECP2 Duplication Syndrome.
Martínez de Paz , A., Sanchez-Mut , J.V., Mireia Samitier-Martí, M,, Petazzi, P., Sáez, M., Szczesna, K., Huertas, D., Esteller , M., Ausió, J. (2015). Circadian Cycle-Dependent MeCP2 and Brain Chromatin Changes. PLOS (Public Library of Science),