Tag Archives: Research

1st International MECP2 Duplication Syndrome Family Conference

Texas Children's Hospital26-27 May 2011 The first 1st International MECP2 Duplication Syndrome Family Conference in Houston, Texas was attended by approximately 200 people representing 45 families. There were three major components to the conference: [1] scientific and clinical presentations, [2] data collection for ongoing research, and [3] social events for families. Continue reading

Request for info from Moms

Monica Coenraads is the Executive Director of the Rett Syndrome Research Trust. She feels that there might be something useful for understanding both Rett Syndrome and MECP2 Duplication Syndrome to be learned from women who carry the MECP2 duplication but do not have symptoms. Typically these would be moms or sisters of boys with MECP2 Duplication syndrome. She is looking for women or girls who have the duplication, are free of symptoms, have been tested for skewing (the selective inactivation of the X chromosomes with the duplication), and have been found to have normal skewing. If you happen to fit this profile, please consider contacting Monica. Continue reading

Dr. Zoghbi’s June 2009 NIH Lecture

Dr. Huda Zoghbi agve a great lecture on “Neurobiology of Rett syndrome and related disorders” in June 2009 for the National Institute of Health. parts of the one-hour lecture are technical but much of it in plain language. The lecture does a great job of describing how MECP2 Duplication Syndrome was discovered and some of the similarities and differences between MECP2 Duplication Syndrome. Its well worth watching. Continue reading

MECP2 and Stem Cell Aging

22 January 2010 – Philadelphia, PA, USA Researchers at the Sbarro Institute for Molecular Medicine and Cancer Research at Temple University in Philadelphia and the Human Health Foundation in Spoleto, Italy have reported on another potentially important role for the MECP2 gene. Their study, reported in the Journal of the Federation of American Societies for Experimental Biology, indicates that properly regulated MECP2 is important in the aging of stem cells, potentially impacting on the ability of stem cells to assist the body in repairing and replenishing other cells. Continue reading

MECP2 and Stress

8 November 2009 For some time, researchers at McGill Univeristy have been doing interesting research on stress in mice. Michael Meaney, Moische Szyf, and others at McGill have shown that stressed mother mice treat their babies differently and this stresses the babies, but the surprising thing is that the babies grow up to respond excessively to stress, as a result this second generation of mothers also become stressed mothers, whose behavior then stresses their babies and thus stress is transmitted from generation to generation. Continue reading